In March 2003 work was commenced on the Epworth Eastern hospital at Box Hill, at a cost of $85 Million. The hospital had a 210-bed facility completed in April 2005 and opened to patients on 30th May 2005. Epworth has also extended its existing partnership with Peter Mac at the Box Hill site. Peter Mac has three radiotherapy bunkers at the Epworth Eastern Medical Centre (formerly known as Box Hill Gardens Medical Centre).

Eventually the new six-storey building will have an air bridge linking it to the existing Box Hill Hospital, which will provide prompt and easy access between the two hospitals for doctors, patients and clinical staff.

For many years the Lions Club of Box Hill has provided support for the Box Hill Hospital, and with the arrival of a new hospital in the area the club looked at ways it could provide support for the new facility and the community. As a result patients undergoing chemotherapy at Box Hill's new Epworth Hospital will be seated in comfort thanks to a donation from the Box Hill Lions.

The Box Hill Lions Club presented Dr Peter Hughes, Chief Executive Officer of Epworth Hospital, with a cheque for $22,500, to pay for the recliners in the Chemo Unit. The recliners selected are unique in that they have inbuilt trays for allowing easy access to insert patient IV's and can also double as a tray for the patient's morning tea.